After graduating from Yeditepe University Genetics and Bioengineering Department in 2014, I was accepted as a research assistant at the Harvard- MIT Division of Health Science and Technology (HST), Harvard Medical School, Brigham and Women’s Hospital, Khademhosseini Lab, Cambridge, MA on a 1-year project about the development of next generation anti-cancer drug based on multi-functional Salmonella using tumor-on-a-chip test platform. In addition, I also worked on a project aiming at promoting the polarization of macrophages towards an M2 phenotype in micropatterned 3D hydrogels. Before obtaining my M.Sc degree, I worked as a flow cytometry specialist at the Center for Regenerative Medicine and Stem Cell Research & Manufacturing at Liv Hospital, Istanbul, Turkey. My responsibilities included implementing cell culture techniques, performing flow cytometry analysis, genetic analysis, gene expression analysis, telomerase activity tests and mycoplasma detection of the biological products (cell/tissue products) produced in the GMP (Good Manufacturing Practices) laboratories, before application to the patients. I completed my M.Sc. degree in Biotechnology at Yeditepe University between 2015-2017 with a high honors degree. My thesis study focused on developing nanoparticles for intracellular BIKDDA delivery for the treatment of prostate cancer (Kocak, P., Oz, U. C., Bolat, Z. B., Ozkose, U. U., Gulyuz, S., Tasdelen, M. A., ... Telci, D. (2020). The utilization of poly(2-ethyl-2-oxazoline)-b-poly(ε-caprolactone) ellipsoidal particles for intracellular BIKDDA delivery to prostate cancer. Macromolecular Bioscience, e2000287). During my Ph.D. training, I started working on exosomes and exosome engineering and I am one of the inventors of an international patent on the use of plant derived exosomes for the treatment of small cell lung cancer for the first time (US Patent 10,881,706, 2021). I also worked on the effect of wheat derived exosomes on wound healing during my Ph.D. thesis. I was also involved in various projects which concentrated on the development of therapeutic approaches with using exosomes and engineered exosomes. During my Ph.D. training, I joined Dr. Su Ryon Shin's group at BIRC Division of
POLEN KOÇAK Engineering in Medicine at BWH, Harvard Medical School, as a visiting researcher (2019-2020). Within this group, I mainly focused on the ongoing research related to cardiac reprogramming using miRNA loaded exosomes, liposomes and hybrid nanoparticles. By actively participating in this project, I had a chance to enrich my professional development in areas needed for successful collaboration with other disciplines besides strengthening the interdisciplinary contributions and capabilities. Consequently, I believe I have gained a profound knowledge of experimental and theoretical concepts of tissue Engineering which will enable me to perform sophisticated experiments and interpret the data. Lastly, I am the co-founder of Genestetix Biotechnology which is an R&D start up that develops artificial intelligence-supported personalized genetic test kits and personalized biotechnological products within the Incubation Center of Acıbadem University. I am also one of the founding members of the Artificial Intelligence and Technology Association in Turkey.